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ThinPrep Non-Gyn Test

Hologic remains committed to providing laboratories with innovative and effective cytology solutions, such as the Health Canada and FDA approved, ThinPrep Non-Gyn test, which has been used in laboratories around the world for more than 15 years.

The Thin-Prep Non-Gyn test offers a standardized specimen preparation method for a variety of cytologic specimens — the slides are easier and less time-consuming to screen and interpret,1 supporting lab efficiency and business growth.

One slide provides a complete picture 

The ThinPrep Non-Gyn test combines quality and efficiency; one instrument can standardize your slide preparation for all non-gyn cases. The test produces a single, well-preserved representative slide per case using standardized processing. This decreases screening time per slide to support your combined goals of quality and efficiency, ultimately helping your lab take on new business and continue to grow.

The ThinPrep Non-Gyn test delivers:
Greater clarity and detail2:
  • Well-preserved cells, ensuring specimen integrity.
  • Reduced clumping and overlapping with minimal background debris, enhancing microscopic examination.
  • Uniform distribution of cells presented on a clear background, revealing important details.
Representative sampling and enhanced presentation for reduced screening time:
  • One well-preserved slide, representative of the entire patient sample.
  • Cells limited to a smaller 20 mm diameter, providing a concentrated screening area.
  1. Hees K, Lebeau PB. Comparison of conventional and ThinPrep preparations of mucoid cytology samples. Diagn Cytopathol. 1995;12:181-5.
  2. Papillo JL, Lapen DC. Cell yield: ThinPrep vs. cytocentrifuge. Acta Cytol. 1994;38(1):33-6.

Fine Needle Aspirates (FNA) – Breast

Ayata G, Wang HH. Fine needle aspiration cytology of lobular carcinoma in situ on ThinPrep. Diagn Cytopathol. 2005;32(5):276-80.

Bartels P, Fabian C, Kimler B, Ranger-Moore J, Frank D, Yozwiak M, AlbertsD. Karyometry of breast epithelial cells acquired by random periareolar fine needle aspiration in women at high risk for breast cancer. Anal Quan CytolHistol. 2007;29(2)63-70.

Beatty BG, Bryant R, Wang W, Ashikaga T, Gibson PC, Leiman G, Weaver DL. HER-2/neu detection in fine-needle aspirates of breast cancer: fluorescence in situ hybridization and immunocytochemical analysis. Am J Clin Pathol. 2004;122(2):246-55.

Bedard YC, Pollet AF. Breast fine-needle aspiration: a comparison ofThinPrep and conventional smears. Am J Clin Pathol. 1999;111:523-7.

Biscotti CV, Hollow JA, Toddy SM, Easley KA. ThinPrep vs. conventional smear cytologic preparations in analyzing fine-needle aspiration specimens from palpable breast masses. Diagn Cytopathol. 1999;21(2):137-41.

Ernst LM, Rimm DL. Quantitative examination of mechanophysical tumor cell enrichment in fine-needle aspiration specimens. Diagn Cytopathol. 2002;96(5):275-9.

Gornstein B, Jacobs T, Bedard Y, Biscotti C, Ducatman B, Layfield L, McKee G, Sneige N, Wang H. Interobserver agreement of a probabilistic approach to reporting breast fine-needle aspirations on ThinPrep. DiagnCytopathol. 2004;30(6):389-95.

Lankford KV, Kluskens L, Dowlatshahi K, Reddy V, Gattuso P. Utilization of core wash material in the diagnosis of breast lesions by stereotactic needle biopsy. Cancer. 1998;84(2):98-100.

Myers T, Wang HH: Fibroadenoma mimicking papillary carcinoma onThinPrep of fine-needle aspiration of the breast. Arch Pathol Lab Med. 2000;124(11):1667-9.

Perez-Reyes N, Mulford DK, Rutkowski MA, Logan-Young W, Dawson AE. Breast fine-needle aspiration: A comparison of thin-layer and conventional preparation. Am J Clin Pathol. 1994;102:349-53.

Fine Needle Aspirates (FNA) – Endoscopic Ultrasound

Chhieng DC, Jhala D, Jhala N, Eltoum I, Chen VK, Vickers S, Heslin MJ, Wilcox CM, Eloubeidi MA. Endoscopic ultrasound-guided fine-needle aspiration biopsy. Cancer (Cancer Cytopathol). 2002;96(4):232-9.

Jhala NC, Jhala D, Eloubeidi MA, Chhieng DC, Crowe DR, Roberson J,Eltoum I. Endoscopic ultrasound-guided fine-needle aspiration biopsy of the adrenal glands. Cancer. 2004;102(5):308-14.

Meara RS, Jhala D, Eloubeidi MA, Eltoum I, Chhieng DC, Crowe DR,Varadarajulu S, Jhala N. Endoscopic ultrasound-guided FNA biopsy of bile duct and gallbladder: analysis of 53 cases. Cytopathology. 2006;17(2):42-9.

Fine Needle Aspirates (FNA) – Liver and Pancreas

Centeno BA, Warshaw AL, Mayo-Smith W, Southern JF, Lewandrowski K.Cytologic diagnosis of pancreatic cystic lesions. A prospective study of 28percutaneous aspirates. Acta Cytol. 1997;41(4):972-80.

De Luna R, Eloudeidi MA, Sheffield MV, Eltoum I, Jhala N, Jhala D, ChenVK, Chhieng DC. Comparison of ThinPrep and conventional preparations in pancreatic fine-needle aspiration biopsy. Diagn Cytopathol. 2004;30(2):71-6.

Nagle JA, Wilbur DC, Pitman MB. Cytomorphology of gastric and duodenal epithelium and reactivity to B72.3: a baseline for comparison to pancreatic lesions aspirated by EUS-FNAB. Diagn Cytopathol. 2005;33(6):381-6.

Sariya D, Kluskens L, Assad L, Treaba D, Reddy V, Gattuso P. Diagnostic role of fine-needle aspiration of pancreatic allograft to detect rejection. DiagnCytopathol. 2002;27(5):266-70.

Siddiqui MT, Gokaslan ST, Saboorian MH, Ashfaq R. Split sample comparison of ThinPrep and conventional smears in endoscopic retrogradecholangiopancreatography-guided pancreatic fine-needle aspirations. DiagnCytopathol. 2005;32(2):70-5.

Fine Needle Aspirates (FNA) - Lung

Konofaos P, Tomos P, Malagari K, Karakatsani A, Pavlopoulos D, LachanasE, Flessas M, Kostakis A, Karakitsos P. The role of ThinPrep cytology in the investigation of lung tumors. Surg Oncol. 2006;15(3):173-8.

Papadopoulos O, Konofaos P, Georgoulakis J, Chrisostomidis C, Tsantoulas Z, Kostopoulos E, Stratigos A, Karipidis D, Karakitsos P. The role ofThinPrep cytology in the investigation of SLN status in patients with cutaneous melanoma. Surg Oncol. 2007;16(2):121-9.

Wallace WA, Monaghan H, Salter DM, Gibbons MA, Skwarski KM. Endobronchial ultrasound guided fine needle aspiration and liquid based thin layer cytology. J Clin Pathol. 2006;60(4):388-91.

Fine Needle Aspirates (FNA) – Salivary Gland

Al-Khafaji BM, Afify AM. Salivary gland fine needle aspiration using theThinPrep technique. Acta Cytol. 2001;45:567-74.

Parfitt JR, McLachlin CM, Weir MM. Comparison of ThinPrep and conventional smears in salivary gland fine-needle aspiration biopsies. Cancer(Cancer Cytopathol). 2007;111(2):123-9.

Fine Needle Aspirates (FNA) – Thyroid and Endocrine

Afify AM, Liu J, Al-Khafaji BM. Cytologic artifacts and pitfalls of thyroid fine-needle aspiration using ThinPrep. Cancer (Cancer Cytopathol). 2001;93(3):179-86.

Biscotti CV, Shorie JH, Gramlich TL, Easley KA. ThinPrep vs. conventional smear cytologic preparations in the analysis of thyroid fine-needle aspirations specimens. Am J Clin Pathol. 1995; 104(2):150-3.

Cheung CC, Carydis B, Ezzat S, Bedard YC, Asa SL. Analysis of ret/PTC gene rearrangement refines the fine needle aspiration diagnosis of thyroid cancer. J Clin Endocrinol Metab. 2001;86(5):2187-90.

Cochand-Priollet B, Prat JJ, Polivka M, Thienpont L, Dahan H, Wassef M, Guillausseau PJ. Thyroid fine-needle aspiration: the morphological features ofThinPrep slide preparations. Eighty cases with histological control.Cytopathology. 2003;14:343-9.

Ford L, Rasgon BM, Hilsinger RL, Cruz RM, Axelsson K, Rumore GJ, Schmidtknecht TM, Puligandla B, Sawicki J, Pshea W. Comparison of ThinPrepversus conventional smear cytopreparatory techniques for fine-needle aspiration specimens of head and neck masses. Otolaryngol Head Neck Surg. 2002;126(5):554-61.

Frost AR, Sidawy MK, Ferfelli M, et al. Utility of thin-layer preparations in thyroid fine-needle aspiration: Diagnostic accuracy, cytomorphology, and optimal sample preparation. Cancer (Cancer Cytopathol). 1998;84:17-25.

Malle D, Valeri RM, Pazaitou-Panajiotou K, Kiziridoe A, Vainas I, Destouni C. Use of thin-layer technique thyroid fine needle aspiration. Acta Cytol. 2006;50(1):23-7.

Michael CW, Pang Y, Pu RT, Hasteh F, Griffith KA. Cellular adequacy for thyroid aspirates prepared by ThinPrep: how many cells are needed? DiagnCytopathol. 2007;35(12):792-7.

Scurry JP, Duggan MA. Thin layer compared to direct smear in thyroid fine needle aspiration. Cytopathology. 2000;11:104-15.

Stamataki M, Anninos D, Brountzos E, Georgoulakis J, Panayiotides J, Christoni Z, Peros G, Karakitsos P. The role of liquid-based cytology in the investigation of thyroid lesions. Cytopathol. 2008;19:11-8.

Tulecke MA, Wang HH. ThinPrep for cytologic evaluation of follicular thyroid lesions: correlation with histologic findings. Diagn Cytopathol. 2004;30(1):7-13.

Zhang Y, Fraser JL, Wang HH. Morphologic predictors of papillary carcinoma on fine-needle aspiration of thyroid with ThinPrep preparations.Diagn Cytopathol. 2001;24(6):378-83.

Fine Needle Aspirates (FNA) – Other

Brandao GD, Rose R, McKenzie S, Maslak P, Lin O. Grading follicular lymphomas in fine-needle aspiration biopsies: the role of ThinPrep slides and flow cytometry. Cancer (Cancer Cytopathol). 2006;108(5):319-23.

Crapanzano JP, Ali SZ, Ginsberg MS, Zakowski MF. Chordoma: a cytologic study with histologic and radiologic correlation. Cancer (Cancer Cytopathol). 2001;93:40-51.

Dey P, Luthra UK, George J, Zuhairy F, George SS, Haji BI. Comparison of ThinPrep and conventional preparations on fine needle aspiration cytology material. Acta Cytol. 2000;44(1):46-50.

Grimbizis G, Mikos T, Pantazis K, Athanassiou E, Sevastiadou P, Papanicolaou A, Polychronou P, Goulis D, Tarlatzis B, Bontis JN, Papadimas I. ThinPrep smears are superior to conventional smears in the cytologic diagnosis of subfertile men by testicular fine-needle aspiration. Diagn Cytopathol. 2008;36(1):1-7.

Guiter GE Gatscha RM, Zakowski MF. ThinPrep vs. conventional smears in fine-needle aspirations of sarcomas: A morphological and immunocytochemical study. Diagn Cytopathol. 1999;21(5):351-4.

Ho C, Khalil M, Duggan A. Higher diagnostic accuracy with the ThinPrep method in a simulated intraoperative environment. Cytopathol. 2007; December 7 [Epub ahead of print].

Lee KR, Papillo JL, St. John T, Eyerer GJA. Evaluation of the ThinPrep Processor for fine needle aspiration specimens. Acta Cytol. 1996;40:895-9.

Michael CW, Hunter B. Interpretations of fine-needle aspirates processed by the ThinPrep technique: Cytologic artifacts and diagnostic pitfalls. Diagn Cytopathol. 2000;23(1);6-13.

Nasuti JF. Utility of the ThinPrep technique in thyroid fine needle aspiration: optimal vs. practical approaches. Acta Cytol. 2006;50(1):3-4.

Papadopoulos O, Konofaos P, Tsantoulas Z, Chrisostomidis C, Frangoulis M, Karakitsos P. Lip defects due to tumor excision: apropos of 899 cases. Oral Oncol. 2007;43(2):204-12.

Salhadar A, Massarini-Wafai R, Wojcik E. Routine use of ThinPrep method in fine-needle aspiration material as an adjunct to standard smears. Diagn Cytopathol. 2001;25:101-3.

Wieczorek TJ, Krane JF, Domanski HA, Akerman M, Carlen B, Misdraji J, Granter SR. Cytologic findings in granular cell tumors, with emphasis on the diagnosis of malignant granular cell tumor by fine-needle aspiration biopsy. Cancer (Cancer Cytopathol). 2001;93(6):398-408.


Choi YD, Han CW, Kim JH, Oh IJ, Lee JS, Nam JH, Juhng SW, Park CS. Effectiveness of sputum cytology using ThinPrep method for evaluation of lung cancer. Diagn Cytopathol. 2008;36(3):167-71.

Crapanzano JP, Zakowski MF: Diagnostic dilemmas in pulmonary cytology. Cancer. 2001;93(6):364-75.

Hees K, Lebeau PB. Comparison of conventional and ThinPrep preparations of mucoid cytology samples. Diagn Cytopathol. 1995;12:181-5.

Rana DN, O'Donnell M, Malkin A, Griffin M. A comparative study: conventional preparation and ThinPrep 2000 in respiratory cytology. Cytopathology. 2001;12:390-8.

Wang HH, Sovie S, Trawinski G et al. ThinPrep processing of endoscopic brushing specimens. Am J Clin Pathol. 1996;105:163-7.

Wiatrowska BA, Krol J, Zakowski MF. Large-cell neuroendocrine carcinoma of the lung: proposed criteria for cytologic diagnosis. Diagn Cytopathol. 2001;24:58-64.

Ylagan LR, Zhai J. The value of ThinPrep and cytospin preparation in pleural effusion cytological diagnosis of mesothelioma and adenocarcinoma. Diag Cytopathol. 2005;32(3):137-44.

Zimmerman RL, Montone KT, Fogt F, Norris AH. Ultra fast identification of Aspergillus species in pulmonary cytology specimens by in situ hybridization. Int J Mol Med. 2000;5(4):427-9.

Superficial Brushings and Scrapings

Duggan MA, Brasher P, Medlicott SA. ERCP-directed brush cytology prepared by the Thinprep method: test performance and morphology of 149 cases. Cytopathology. 2004;15(2):80-6.

Garcia FU, Haber MH, Butcher J, Sharma M, Nagle D. Increased sensitivity of anal cytology in evaluation of internal compared with external lesions. Acta Cytol. 2007;51:893-9.

Kobayashi TK, Ueda M, Nishino T, Ishida Y, Takamura E, Tsubota K. Cytologic evaluation of conjunctival epithelium using Cytobrush-S: value of slide preparation by ThinPrep technique. Cytopathology. 1997;8:381-7.

Kobayashi TK, Tsubota K, Takamura E, Sawa M, Oh-Hashi Y, Usui M. Effect of retinol palmitate as a treatment for dry eye: a cytological evaluation. Ophthalmologica. 1997;211:358-61.

Kobayashi TK, Ueda M, Nishino T, Kibe S, Higashida T, Watanabe S. Scrape cytology of pemphigus vulgaris of the nipple: a mimicker of Paget's Disease. Diagn Cytopathol. 1997;16:156-9.

Kobayaski TK, Takamura E, Tsubota K. Cytologic evaluation of ocular lesions in Schmidt(ed): Review in Pathology. Cytopathology Annual. 1996. Chicago, ASCP Press, 1996, pp 97-128.

Kontzoglou K, Moulakakis KG, Alexiou D, Safioleas MC, Nikiteas N, Giahnaki AE, Kyroudes A, Kostakis A, Karakitsos P. The role of liquid-based cytology in the investigation of colorectal lesions: a cytohistopathological correlation and evaluation of diagnostic accuracy. Langenbecks Arch Surg. 2007;392(2):189-95.

Navone R, Burlo P, Pich A, Pentenero M, Broccoletti R, Marsico A, Gandolfo S. The impact of liquid-based oral cytology on the diagnosis of oral squamous dysplasia and carcinoma. Cytopathology. 2007;18:356-60.

Sheehan MM, Fraser A, Ravindran R, McAteer. Bile duct brushings cytology – improving sensitivity of diagnosis using the ThinPrep technique: a review of 113 cases. Cytopathol. 2007;18:225-33.

Siddiqui MT, Gokaslan ST, Saboorian MH, Carrick K, Ashfaq R. Comparison of ThinPrep and conventional smears in detecting carcinoma in bile duct brushings. Cancer. 2003;99(4):205-10.

Volmar K, Vollmer R, Routbort M, Creager A. Pancreatic bile duct brushing cytology in 1000 cases. Cancer (Cancer Cytopathol). 2006;108(4):231-8.

Ylagan L, Liu L, Maluf H. Endoscopic bile duct brushing of malignant pancreatic biliary strictures: retrospective study with comparison of conventional smear and ThinPrep techniques. Diagn Cytopathol. 2003;28(4):196-204.

Urine Cytology Studies

Bollmann M, Heller H, Bankfalvi A, Griefingholt H, Bollmann R. Quantitative molecular urinary cytology by fluorescence in situ hybridization: a tool for tailoring surveillance of patients with superficial bladder cancer? BJU International. 2005;95(9):1219-25.

Cardillo M, Reuter VE, Lin O. Cytologic features of the nested variant of urothelial carcinoma. Cancer. 2003;99(1):23-7.

Hattori M, Ohno E, Kakinuma H, Uchida T, Kuramoto H. Comparative image analysis of cells in voided and catheterized urine. Anal Quant Cytol Histol. 2002;24(3):154-8.

Hwang EC, Park SH, Jung SI, Kwon DD, Park K, Ryu SB, Park CS. Usefulness of liquid-based preparation in urine cytology. Int J Urol. 2007;14(7):626-9.

Kim DY, Cho HJ, Oh HK, Shin IH, Jeon CH. Comparison of the urine ThinPrep Pap Test and melanoma antigen gene RT-PCR for the detection of bladder cancer according to three urine collection method. Korean J Lab Med. 2007;27(1):50-5.

Kipp BR, Campion MB, Coffman E, Smith A, Tomisek JD, Browne GG, Panella JR, Desai R, Harwood AR, Halling KC. An evaluation of ThinPrep UroCyte filters for the preparation of slides for fluorescence in situ hybridization. Diagn Cytopathol. 2006 ;34(7):479-84.

Lodde M, Mian C, Negri G, Vittadello F, Comploj E, Palermo S, Staffler A, Brossner C, Pycha A. Effect of intravesical instillation on performance of uCYT+ test. Urology. 2004;63(5):878-81.

Lodde M, Mian C, Negri G, Berner L, Nicola M, Lusuardi L, Palermo S, Marberger M, Brossner C, Pycha A. Role of uCyt+ in the detection and surveillance of urothelial carcinoma. Urology. 2003;61(1):243-6.

Maitra A, Rathi A, Gazdar AF, Sagalowsky A, Ashfaq R. Expression of the RNA component of human telemorase (hTR) in ThinPrep preparations from bladder washings. Cancer (Cancer Cytopathol). 2001;93:73-9.

Mian C, Lodde M, Comploj E, Negri G, Egarter-Vigl E, Lusuardi L, Palermo S, Marberger M, Pycha A. Liquid-based cytology as a tool for the performance of uCyt+ and Urovysion multicolour-FISH in the detection of urothelial carcinoma. Cytopathology. 2003;14:338-42.

Nassar H, Ali-Fehmi R, Madan S. Use of ThinPrep monolayer technique and cytospin preparation in urine cytology: a comparative analysis. Diagn Cytopathol. 2003;28(3):115-8.

Piaton E, Faynel J, Hutin K, Ranchin MC, Cottier M. Conventional liquid-based techniques versus ThinPrep processing of urinary samples: a qualitative approach. BMC Clin Pathol. 2005;5-9.

Piaton E, Faynel J, Ruffion A, Lopez JG, Perrin P, Devonec M. p53 immunodetection of liquid-based processed urinary samples helps to identify bladder tumors with a higher risk of progression. Br J Cancer. 2005;93(2):242-7.

Piaton E, Hutin K, Faynel J, Ranchin MC, Cottier M. Cost efficiency analysis of modern cytocentrifugation methods versus liquid based ( ThinPrep) processing of urinary samples. J Clin Pathol. 2004;57(11):1208-12.

Politi EN, Lazaris AC, Lambropoulou S, Alexopoulou D, Kyriakidou V, Koutselini H. Epidermal growth factor receptor and proliferating cell nuclear antigen expression in urine ThinPrep specimens. Cytopathology. 2005;16(6):303-8.

Pycha A, Lodde M, Comploj E, Negri G, Egarter-Vigl E, Vittadello F, Lusuardi L, Palermo S, Mian C. Intermediate-risk urothelial carcinoma: an unresolved problem? Urology. 2004;63(3):472-5.

Sng K, Nga M, Tan S, Walker T. Analysis of urine cytology tests in 120 paired cases. Acta Cytol. 2007;51:782-7.

Wright RG, Halford JA. Evaluation of thin-layer methods in urine cytology. Cytopathology. 2001;12:306-13.

Cytology Review Articles

Fischler DF, Toddy SM. Nongynecologic cytology utilizing the ThinPrep Processor. Acta Cytol. 1996; 40(4):669-75.

Hasteh F, Pang Y. Do we need more than one ThinPrep to obtain adequate cellularity in fine needle aspiration? Diagn Cytopathol. 2007;35(11):740-3.

Hoda R. Non-gynecologic cytology on liquid-based preparations: a morphologic review of facts and artifacts. Diagn Cytopathol. 2007;35(10):621-34.

Leung CS, Chiu B, Bell V. Comparison of ThinPrep and conventional preparations: nongynecologic cytology evaluation. Diagn Cytopathol. 1997;16(4):368-71.

Nasuti JF, Tam D, Gupta PK. Diagnostic value of liquid-based (ThinPrep) preparations in nongynecologic cases. Diagn Cytopathol. 2001;24:137-41. Editorial.

Papillo JL, Lapen DC. Cell yield: ThinPrep vs. cytocentrifuge. Acta Cytol. 1994;38(1):33-6.

Thiryayi SA, Rana DN, Perera DM. Bronchial Cardinoid Tumor. Cytologic features on ThinPrep and a diagnostic pitfall in bronchial brushings and washings. Diagn Cytopathol. 2008;36(4):275-6. Editorial.

Case Reports

Erhardt CA, Vesoulis Z, Kashkari S. Fine needle aspiration cytology of cellular hemangioma of infancy. Acta Cytol. 2000; 44(6):1090-4.

Gaffney RL, Fedderson RM, Bocklage TJ, Joste NE. Fine needle aspiration cytology of follicular dendritic cell sarcoma. Acta Cytol. 2000;44:809-14.

Hendsch SA, Glover SD, Otis CN, Donovan JT. Atypical glandular cells of undetermined significance from extramammary Paget's of the bladder. Obstet Gynecol. 2002; 99(5 Pt 2):912-4.

Ioakim-Liossi A, Mikou P, Botsoli-Stergiou E, Petrakakou E, Athanassiadou P, Kordosis T, Panagoptakopoulos G, Karakitsos P. Primary effusion lymphoma. A case report. Acta Cytol. 2004; 48(2):269-72.

Jaffer S, Woodruff J. Cytology of melanotic schwannoma in a fine needle aspirate and pleural fluid. Acta Cytol. 2000;44(6):1095-100.

Kobayashi TK, Ueda M, Nishino T, Tamagaki T, Watanabe S, Kushima R. Malignant pleural effusions due to adeno-endocrine-cell carcinoma of the appendix: a case report. Diagn Cytopathol. 1997;16:522-5.

Kobayaski TK, Ueda M, Nishino T, Muramatsu M, Moritani S, Seki H, Araki H, Kaneko C. Papillary clusters as a diagnostic pitfall in urinary cytology of pseudosarcomatous fibromyxoid tumor of the bladder. A Case Report. Acta Cytol. 2003;47:1069-73.

Kobayashi TK, Ueda M, Nishino T, Muramatsu M, Moritani S, Shigematsu T, Kohno Y, Kaneko C, Kushima R. Eosinophilic ascites. Cytopathol. 2003;14:84-6.

Kobayashi TK, Moritani S, Urabe M, Bamba M, Ueda M, Nishino T, Muramatsu M, Kaneko C. Cytologic diagnosis of endosalpingiosis with pregnant women presenting in peritoneal fluid. A case report. Diagn Cytopathol. 2004;30:422-5.

Leon ME, Deschler D, Wu SS, Galindo LM. Fine needle aspiration diagnosis of lipoblastoma of the parotid region. Acta Cytol. 2002;46(2):395-404.

Pantanowitz L, Galan A, Gang D, Crisi G, LaPolice P, Goulart R. Diagnostic cytology features of an epididymal melanotic neuroectodermal tumor of infancy present in scrotal fluid. Acta Cytol. 2006;50:460-5.

Pantidou A, Kiziridou A, Antoniadis T, Tsilikas C, Destouni C. Mediastinum thymoma diagnosed by FNA and ThinPrep technique: a case report. Diagn Cytopathol. 2006;34(1):37-40.

Porcell AI, Hitchcok CL, Keyhani-Rofagha S. Use of immunohistochemistry in fine needle aspiration of thyroid nodules in patients with a history of malignancy. A report of two cases. Acta Cytol. 2000; 44:393-8.

Sarode VR, Castellani R, Post A. Fine-needle aspiration cytology and differential diagnoses of fibromellar hepatocellular carcinoma metastatic to the mediastinum. Diagn Cytopathol. 2002;26(2):95-8.

Shapiro SL, McMenomey SO, Alexander P, Schmidt WA. Fine-needle aspiration biopsy diagnosis of "invasive" temporomandibular joint pigmented villonodular synovitis. Arch Pathol Lab Med. 2002; 126(2):195-8.

Stopyra GA, Warhol MJ, Multhaupt HAB. Utility of CK7 and CK20 immunohistochemistry in the detection of synchronous breast and colon carcinoma in a pleural effusion: a case report and supporting survey of archival material. Diagn Cytopathol. 2001;25(1):54-8.

Tai LH, Johnston JO, Klein HZ, Rowland J, Sudilovsky D. Calcifying aponeurotic fibroma features seen on fine-needle aspiration biopsy: case report and brief review of the literature. Diagn Cytopathol. 2001;24(5):336-9.

Van Ells B, Madory J, Hoda R. Desmoplastic melanoma morphology on ThinPrep: a report of two cases. CytoJournal. 2007;4:18.

Other Studies

Al-Abbadi M, Abuhammour W, Harahsheh A, Abdel-Haq N, Hasan R, Husain S. Conjunctival changes in children with Kawasaki disease. Acta Cytol. 2007;51(3):370-4.

Ali AS, Yin D, Yao D, Vazquez M. Criteria for the diagnosis of fibroepithelial lesions of the breast with liquid-based cytology. Acta Cytol. 2004;48(4):481-6.

Darragh TM, Jay N, Tukelewicz BA, Hogeboom CJ, Holly EA, Palefsky JM. Comparison of conventional cytologic smears and ThinPrep preparations from the anal canal. Acta Cytol. 1997;41(4):1167-70.

Denton K, Rana DN, Lynch MA, Desai MS. Bland dyskaryosis: a new pitfall in liquid-based cytology. Cytopathol. 2007;December 19 [Epub ahead of print].

Elsheikh TM, Kirkpatrick JL, Wu HH. Comparison of ThinPrep and cytospin preparations in the evaluation of exfoliative cytology specimens. Cancer (Cancer Cytoapthol). 2006;108(3):144-9.

Fischler D, Toddy S. Nongynecologic cytology utilizing the ThinPrep Processor. Acta Cytol. 1996;40(4):669-75.

Friedlander MA, Stier R, Lin O. Anorectal cytology as a screening tool for anal squamous lesions: cytologic, anoscopic, and histologic correlation. Cancer. 2004;102(1):19-26.

Goldstone SE, Winkler B, Ufford LJ, Alt E, Palefsky JM. High prevalence of anal squamous intraepithelial lesions and squamous-cell carcinoma in men who have sex with men as seen in surgical practice. Dis Colon Rectum. 2001;44(5):690-8.

Gu M, Shi W, Barakat RR, Thaler HT, Saigo PE. Peritoneal washings in endometrial carcinoma: a study of 298 patients with histopathologic correlation. Acta Cytol. 2000;44(5):783-9.

Illei PB, Ladanyi M, Rusch VW, Zakowski MF. The use of CDKN2A deletion as a diagnostic marker for malignant mesothelioma in body cavity effusions. Cancer (Cancer Cytopathol). 2003;99(1):51-6.

Joste NE, Sax PE, Pieciak WS. Cytologic detection of microsporidia spores in bile. A comparison of stains. Acta Cytol. 1999;43(2):98-103.

Kim SH, Milsom JW, Gramlich TL, et al. Does laparoscopic vs. conventional surgery increase exfoliated cancer cells in the peritoneal cavity during resurrection of colorectal cancer? Dis Colon Rectum. 1998;41(8):971-8.

Lapen DC, Papillo JL. Performance optimization of the ThinPrep Processor: effect of microscope slides. Diagn Cytopathol. 1998;19:388-91.

Lu D, Davila RM, Pinto KR, Lu DW. ThinPrep evaluation of fluid samples aspirated from cystic ovarian masses. Diagn Cytopathol. 2004;30(5):320-4.

Mensch :S, Weller L, Simmons-Arnold L, Gibson PC, Leiman G, Beatty B. GLUT1 antibody staining in thin-layer specimens of benign and malignant body cavity effusions. Acta Cytol. 2002;46(5):813-8.

Michael CW, McConnel J, Pecott J, Afify AM, Al-Khafaji B. Comparison of ThinPrep and TriPath PREP liquid-based preparations in nongynecologic specimens: a pilot study. Diagn Cytopathol. 2001;25:177-84.

Nigro K, Tynski Z, Wasman J, Abdul-Karin F, Wang N. Comparison of cell block preparation methods for nongynecologic ThinPrep specimens. Diagn Cytopathol. 2007;35(10):640-3.

Sadeghi S, Ylagan LR. Pelvic washing cytology in serous borderline tumors of the ovary using ThinPrep: are there cytologic clues to detecting tumor cells? Diagn Cytopathol. 2004;30(5):313-9.

Vajdic CM, Anderson JS, Hillman RJ, Medley G, Grulich AE. Blind sampling is superior to anoscope guided sampling for screening for anal intraepithelial neoplasia. Sex Transm Infect. 2005;81(5):415-8.

Wakely Jr. PE, Menezes G, Nuovo GJ. Primary effusion lymphoma: cytopathologic diagnosis using in situ molecular genetic analysis for human herpes virus 8. Mod Pathol. 2002;15(9):944-50.

Weir MM, Bell DA. Cytologic identification of serous neoplasms in peritoneal fluids. Cancer (Cancer Cytopathol). 2001;93:309-18.

Zhang W, Yang YC, Zhang BN, Pan QJ, Hart SD, Duvall K, Zhang ZF, Rao JY. Biomarker analysis on breast ductal lavage cells in women with and without breast cancer. Int J Cancer. 2006;119(2):359-64.

Zhu W, Michael C. How important is on-site adequacy assessment for thyroid FNA? An Evaluation of 883 Cases. Diagn Cytopathol. 2007;35(3):183-6.

Ancillary Testing: Immunocytochemistry

Bedard YC, Pollett AF, Leung SW, O'Malley FP. Assessment of thin-layer breast aspirates for immunocytochemical evaluation of HER2 status. Acta Cytol. 2003;47(6):979-84.

Chhieng DC, Ko EC, Yee HT, Shultz JJ, Dorvault CC, Eltoum IA. Malignant pleural effusions due to small-cell lung carcinoma: a cytologic and immunocytochemical study. Diagn Cytopathol. 2001; 25(6):356-60.

Dabbs DJ, Abendroth CS, Grenko RT, Wang X, Radcliffe GE. Immunocytochemistry on the ThinPrep Processor. Diagn Cytopathol. 1997;17:388-92.

Dimulescu I, Unger ER, Lee DR, Reeves WC, Vernon SD. Characterization of RNA in cytologic samples preserved in a methanol-based collection solution. Mol Diagn. 1998;3:67-72.

Fadda G, Rossi ED, Mule A, Miraglia A, Vecchio FM, Capelli A. Diagnostic efficacy of immunocytochemistry on fine needle aspiration biopsies processed by thin-layer cytology. Acta Cytol. 2006;50(2):129-35.

Fetsch PA, Simsir A, Brosky K, Abati A. Comparison of three commonly used cytologic preparations in effusion immunocytochemistry. Diagn Cytopathol. 2002;26:61-6.

Fetsch PA, Abati A. Immunocytochemistry in effusion cytology: a contemporary review. Cancer (Cancer Cytopathol). 2001;93(5):293-308.

Gong Y, Sun X, et al. Immunocytochemistry of serous effusion specimens: a comparison of ThinPrep vs cell block. Diagn Cytopathol. 2003;28(1):1-5.

Han AC, Filstein MR, Hunt JV, Soler AP, Knudsen KA, Salazar H. N-cadherin distinguishes pleural mesotheliomas from lung adenocarcinomas: a ThinPrep immunocytochemical study. Cancer. 1999; 87(2):83-6.

Harton AM, Wang HH, Schnitt SJ, Jacobs TW. P36 Immunocytochemistry improves accuracy of diagnosis with fine-needle aspiration of the breast. Am J Clin Pathol. 2007;128:80-5.

Kaplan MA, Segura AM, Wang HH, Schnitt SJ, Upton MP. Evaluation of CytoLyt and PreservCyt as preservatives for immunocytochemistry for cytokeratin in fine needle aspiration. Applied Immunohistochem. 1998;6:23-9.

Kobayashi TK, Ueda M, Nishino T, Terasaki S, Kameyama T. Brush cytology of herpes simplex virus infection in oral mucosa: use of the ThinPrep Processor. Diagn Cytopathol. 1998;18:71-5.

Leung SW, Bedard YC. Estrogen and progesterone receptor contents in ThinPrep-processed fine-needle aspirates of breast. Am J Clin Path. 1999;112:50-6.

Leung SW, Bedard YC. Immunocytochemical staining on ThinPrep processed smears. Mod Pathol. 1996;9:301-6.

Li XJ, Pan QJ, Shen GH, Liu XY, Sun YT. [Differential diagnostic value of B72.3, Ber-EP4 and calretinin in serous effusions] Zhonghua Zhong Liu Za Zhi. 2005;27(7):438-41. Chinese.

Nawgiri R, Nagle J, Wilbur D, Pitman M. Cytomorphology and B72.3 Labeling of benign and malignant ductal epithelium in pancreatic lesions compared to gastrointestinal epithelium. Diagn Cytopathol. 2007;35(5):300-5.

Schofield K, D'Aquila T, Rimm DL. The cell adhesion molecule, E-cadherin, distinguishes mesothelial cells from carcinoma cells in fluids. Cancer (Cancer Cytopathol). 1997;81:293-8.

Tabbara SO, Sidawy MK, Frost AR et al. The stability of estrogen and progesterone receptor expression on breast carcinoma cells stored as PreservCyt suspensions and as ThinPrep slides. Cancer. 1998;84(6):355-60.

Vocaturp A, Novelli F, Benevolo M, Piperno G, Marandino F, Cianciulli A, Merola R, Donnorso R, Sperduti I, Buglioni S, Mottolese M. Chromogenic in situ hybridization to detect HER-2/neu gene amplification in histological and ThinPrep-processed breast cancer fine-needle aspirates: a sensitive and practical method in the trastuzumab era. Oncologist. 2006;11(8):878-86.

Wiatrowska BA, Berner A, Torlakovic G, Emilsen E, Mykelbost GL, Torlakovic E. Cultured anaplastic cell lines as immunocytochemistry controls: a comparison of ThinPrep-processed smears and conventional air-dried cytospins. Diagn Cytopathol. 2001;25(5):303-8.

Wieczorek TJ, Krane JF. Diagnostic utility of calretinin immunohistochemistry in cytologic cell block preparations. Cancer (Cancer Cytopathol). 2000;90:312-9.

Ancillary Testing: In Situ Hybridization

Florentine BD, Sanchez B, Raza A et al. Detection of hyperdipliod malignant cells in body cavity effusions by fluorescence in situ hybridization on ThinPrep slides. Cancer. 1997;81:299-308.

Kurtycz D, Nunez M, Arts T et al. Use of fluorescent in situ hybridization to detect aneuploidy in cervical dysplasia. Diagn Cytopathol. 1996;15:46-51.

Skacel M, Pettay JD, Evangelos KT, Procop GW, Biscotti CV, Tubbs RR. Validation of a multicolor interphase fluorescence in situ hybridization assay for detection of transitional cell carcinoma on fresh and archival thin-layer, liquid-based cytology slides. Anal Quant Cytol Histol. 2001;23:381-7.

Ancillary Testing: PCR

Cheung CC, Carydis B, Ezzat S, Bedard YC. Analysis of ret/PTC gene rearrangements refines the fine needle aspiration diagnosis of thyroid cancer. J Clin Endocrin Metab. 2001;86:2187-90.

Pollett A, Bedard YA, Li SQ, Rohan T, Kandel R. Correlation of p53 mutations in ThinPrep-processed fine needle breast aspirates with surgically resected breast cancers. Mod Pathol. 2000;13(11):1173-9.

Tisserand P, Fouquet C, Marck V, Mallard C, Fabre M, Vielh P, Soussi T. ThinPrep-processed fine-needle samples of breast are effective material for RNA- and DNA-based molecular diagnosis. Cancer (Cancer Cytopathol). 2003; 99(4):223-32.

Ancillary Testing: Special Stains

Echeverri C, Matherne J, Jorgensen JH, Fowler LJ. Fite stain positivity in Rhodococcus equi: yet another acid-fast organism in respiratory cytology: a case report. Diagn Cytopathol. 2001;24(4):244-6.

Ancillary Testing: Other

Politi EN, Lazaris AC, Alexopoulou D, Lambropoulou S, Kavantzas N, Koutselini H. Morphometric analysis of AgNORs in thin-layer, liquid based liver specimens. Anal Quant Cytol Histol. 2004; 26(4):187-93.

Wojcik EM, Saraga SA, Jin JK, Hendricks JB. Application of laser scanning cytometry for evaluation of DNA ploidy in routine cytologic specimens. Diagn Cytopathol. 2001;24:200-5.